First Dose Missions in GTA V Online Complete Walkthrough

How to Get Started On First Dose Missions

To start the First Dose missions in GTA Online, wait for a phone call from Ron Jakowski. There's no rank or property requirement, and the missions are free to launch. After the call you'll find a yellow R on your map at Ace Liquor in Sandy Shores, as pictured above. Head there to begin the first mission. All six missions support 1–4 players, and they can be launched from an invite-only session if you'd rather avoid public lobbies.

First Dose 1 - Welcome to the Troupe

In the first mission you'll meet Dax and the Fooligans. Here's a run-through:

• Arrive at the liquor store and watch the cutscene introducing Dax and the Fooligans.

• Help Dax fight off the enemy group The Lost.

• Head to the Alamo Sea, where a boat is waiting.

• Drive the boat across the Alamo Sea to the blue dot on your map.

• Fight the enemies, making your way up to the orange RV, Dax's Journey II.

• Drive the RV back to the liquor store to pick up Dax while fighting off enemies. Don't let the RV's health meter run out.

• Drive Dax in the RV to the marked location in Los Santos. Run over any enemy motorcyclists you can on the way.

• The mission ends when you reach your destination, as pictured above.

You now have Dax as a contact and can return to him to continue the series. Fooligan Jobs are also unlocked. Like every First Dose mission, completing it as the leader pays a one-time GTA$ 50,000 bonus on top of the regular payout.

First Dose 2 - Designated Driver

To start the second mission, find Dax on your map (the yellow D). He's right outside the Freakshop, so if you just finished part 1 you're already there. Now follow these steps:

• Drive to the Terminal as directed.

• Find the cab of a pickup truck to steal. There are several around.

• Drive the cab to the trailer marked on your map.

• Pull in front of the trailer, then back up to connect.

• Follow the directions back toward the Freakshop.

• A barricade of enemies will block your path. Eliminate them.

• The trailer will inevitably catch fire. Abandon it before it explodes.

• Drive to the clubhouse of The Lost in either the truck cab or a vehicle of your choice.

• Eliminate the Lost club members.

• Inside the clubhouse, find the office with the whiteboard.

• Use your phone's Snapmatic app to take a picture of the whiteboard.

• Grab the black bag on the bar counter.

• Fill the bag with weed from the tables in the clubhouse.

• Exit the clubhouse and head back to the Freakshop to complete the mission.

First Dose 3 - Fatal Incursion

As usual, find the yellow D next to the Freakshop to start First Dose 3. Then follow these steps:

• Follow the directions to Stab City.

• At Stab City, eliminate any enemies and blow up the vans and motorcycles that appear on your radar.

• Once you've destroyed enough property you'll be prompted to head to Millar's Fishery.

• At Millar's Fishery, keep clearing enemies while looking for meth to steal.

• The meth is inside sheds, around the outside of buildings, and on the dock.

• Once you've stolen all the meth, go to the end of the dock and hop in the waiting Mammoth Dodo seaplane.

• An enemy helicopter will chase you, but the Dodo easily outruns it.

• When you reach the city you'll lose the enemies and need to land in the storm drain, marked with a yellow dot.

• Take your time; even if you miss the target you can back up and drive along the storm drain to the yellow dot.

• Land close enough to the yellow dot and the mission is complete.

First Dose 4 - Uncontrolled Substance

Find Dax at the usual place to start this mission, but that's the only usual thing about it. A cutscene shows you, Dax, and a group of Fooligans sharing a beer, but the beer is laced with LSD. What follows is a series of trippy set pieces that switch fairly frequently, usually when you enter a tunnel. You can't fail this mission. You can die, but you'll simply reappear. There's not much to do except enjoy the ride.

First Dose 5 - Make War not Love

Start the mission the same way as the others. Then follow these steps:

• Head to the hippie camp at Senora Desert Trailer Park.

• Once there, eliminate the enemies and their equipment.

• To destroy the equipment inside the tents, shoot the explosive barrels in them.

• Find the hippie van and get inside. It's bright and colorful; you can't miss it.

• Entering the van automatically uses its GPS to locate the delivery vans, which now appear on your radar.

• Track down each of the vans and destroy them.

• Dax will then send you to the Altruist Camp to destroy even more vans plus a helicopter.

• Once everything is destroyed, simply leave the area and you're done.

First Dose 6 - Off the Rails

Once again, head to the Freakshop and the big yellow D to start the final First Dose mission. Then follow these steps:

• Head to Humane Labs and Research.

• You'll be advised to stay in stealth when you arrive. Feel free to, but it really isn't necessary.

• In the shipping garage, find the shipment manifest on a wall near the big garage doors.

• Take a picture with your Snapmatic and send it to Dax.

• Find the crowbar lying nearby and use it to pry open shipping containers and steal their contents.

• Once you've collected all 5 containers of chemicals you'll be told to go stop a train. You have to move fast.

• Race out of Humane Labs toward the yellow dot on your map. We recommend off-roading for the quickest route.

• When you arrive, head upstairs and inside the building to pull the lever.

• The train will drive by and crash. Head to the area indicated on your map to collect a cutter.

• Go to the crash site. Enemies attack on foot, in cars, and one at a time in a helicopter, and they keep coming while you collect the loot.

• Cut open the containers on the crashed train cars.

• Some cars have chemicals inside. Keep checking until you collect all 5.

• With all the chemicals collected, steal the Brickade 6x6, which sits on one of the train cars in the crash site.

• Drive the Brickade back to the Freakshop, avoiding too much damage, to end the mission.

Finishing Off the Rails hands you the Freakshop and the Brickade 6x6 for free, and it starts the path to unlock the Acid Lab in GTA Online. Dax offers a free "Setup: Acid Lab Equipment" mission to steal the lab gear from a nearby warehouse. Once that's done, pay Mutt GTA$ 750,000 at the Freakshop to install the lab in the back of the Brickade. See our Acid Lab business guide and the Acid Lab business page for full setup costs and profits.

Some time later, Dax will contact you for more work, which kicks off the Last Dose missions.

First Dose FAQ

Can you play First Dose missions solo?

Yes. Every First Dose mission supports 1–4 players and is comfortably doable solo. You can also launch them from an invite-only session, so public lobbies are never required.

How much do First Dose missions pay?

Base pay is roughly GTA$ 15,000–20,000 per mission. On top of that, each of the six missions pays a one-time GTA$ 50,000 award when you complete it as the leader, and finishing all six while registered as a CEO, VIP, or MC member earns the one-time GTA$ 100,000 "Back It Up" award. A first full run is worth up to GTA$ 400,000 in bonuses on top of base pay.

Do First Dose missions unlock the Acid Lab?

They start the chain. Finishing all six unlocks the Freakshop and the free Brickade 6x6, plus a free "Setup: Acid Lab Equipment" steal mission. After that you pay Mutt GTA$ 750,000 at the Freakshop to install the lab. Our Acid Lab business guide covers profits, and the Acid Lab business page has the full cost breakdown.

What is the Acid Lab Equipment Upgrade?

Complete 10 Fooligan Jobs for Dax, then buy the Equipment Upgrade from Mutt for GTA$ 250,000. It speeds up acid production and is well worth it if you plan to run the lab regularly.

Do you have to play First Dose missions in order?

Yes. Dax hands out the missions one at a time, in a fixed order, from Welcome to the Troupe through Off the Rails.

Can you fail Uncontrolled Substance?

No. First Dose 4 can't be failed; if you die during the trip you simply reappear and carry on.