First Dose is a series of contact missions for Dax. Working your way through the series you will unlock the Freakshop, the Brickade 6x6, Fooligan Jobs, and Last Dose. It's also a step on the way to unlocking the Acid Lab. You'll also of course earn GTA$ and RP.

Read on for a walkthrough of all 6 missions.


How to Get Started On First Dose Missions

In order to start the First Dose missions you'll get a phone call from Ron Jakowski. After that phone call you'll be able to find a yellow R on your map, as pictured above. Head there to begin the first mission.

First Dose 1 - Welcome to the Troupe

In the first mission you'll meet Dax and the Fooligans. Here's a run-through:

  1. Arrive at the liquor store and watch a cutscene meeting Dax and the Fooligans.
  2. Help Dax fight off enemy group The Lost.
  3. Head to the Alamo Sea where there will be a boat waiting.
  4. Drive the boat across the Alamo Sea to the blue dot on your map.
  5. Fight the enemies, making your way up to the orange RV.
  6. Drive the RV back to the liquor store to pick up Dax while fighting off enemies. Make sure the health meter of the RV doesn't doesn't run out.
  7. Drive Dax in the RV to the location marked on your map in Los Santos. Do your best to run over any enemy motorcyclists on the way.
  8. The mission ends when you reach your destination, as pictured above.

You now have Dax as a contact and will go to him to continue the series. You can also now do Fooligan Jobs.

First Dose 2 - Designated Driver

To start the second mission, find Dax on your map (the yellow D). It's right outside the Freakshop so if you just finished part 1 then you're already there. Now follow these steps:

  1. Drive to the Terminal as directed.
  2. Find a the cab of a pickup truck to steal. There are several around.
  3. Now drive the cab to the trailer, marked on your map.
  4. Drive in front of the trailer, then back up to connect.
  5. Follow the directions to head back to the Freakshop.
  6. There will be a barricade of enemies in your path. Eliminate them.
  7. Inevitably the trailer will catch fire. Abandon it before it explodes.
  8. Now drive to the clubhouse of The Lost in either the truck cab or your own vehicle of choice.
  9. Eliminate the Lost club members.
  10. Inside the clubhouse find the office where there's a whiteboard.
  11. Use your phone Snapmatic app to take a picture of the whiteboard.
  12. Find a black bag in the clubhouse on the bar counter.
  13. Fill the back with weed from the tables in the clubhouse.
  14. Exit the clubhouse and head back to the Freakshop to complete the mission.

First Dose 3 - Fatal Incursion

As usual, find the yellow D on your map, next to the Freakshop, to start First Dose Part 3. Then follow these steps:

  1. Follow the directions to Stab City.
  2. At Stab City, eliminate any enemies and blow up vans and motorcycles that appear on your radar.
  3. Once you've destroyed enough property you'll be prompted to head to Miller's Fishery.
  4. At Miller's Fishery continue to destroy any enemies while also looking for meth to steal.
  5. The meth will be inside sheds, around the outside of buildings, and on the dock.
  6. Once you steal all the meth go to the end of the dock and hop on the Dodo.
  7. An enemy helicopter will start to follow you but you should be able to easily outrun it.
  8. When you get into the city you'll lose the enemies and need to land in the storm drain, mark with a yellow dot.
  9. Take your time; Even if you miss your target you can always back up and drive along the storm drain to the yellow dot.
  10. Once you land close enough to the yellow dot the mission will be complete.

First Dose 4 - Uncontrolled Substance

Find Dax at the usual place to start this mission. But that's the only thing about this one that's uaul. You'll see a cutscene in which you, Dax, and a group of Fooligans have a beer together, but the beer is laced with LSD. What ensues is a series of situations that transition fairly frequently, usually via entering tunnels. You can't fail this mission. You can die, but you'll just reappear. There's not much you can do except to enjoy the ride.

First Dose 5 - Make War not Love

Start the mission the same way as the others. Then follow these steps:

  1. Head to the Hippie camp at Senora Desert Trailer Park.
  2. Once there, eliminate enemies and their equipment.
  3. To destroy the equipment in the tents, simply shoot at the explosive barrels inside of them.
  4. Next you'll need to find a hippie van and get inside. It's bright and colorful. You can't miss it.
  5. When you enter the hippie van you'll automatically use its GPS to locate the delivery vans. Those will now appear on your radar.
  6. Track down each of the vans and destroy them.
  7. After that Dax will have you head to the Altruist Camp to destroy even more vans as well as a helicopter.
  8. Once all is destroyed, simply vacate the premises and you're done.

First Dose 6 - Off the Rails

Once again, head to the Freakshop and the big yellow D to start the final First Dose mission. Then follow these steps:

  1. Head to Humane Labs and Research.
  2. When you get there you'll be advised to remain in stealth. Feel free to do so, but it really isn't necessary.
  3. When you get into the shipping garage find the shipment manifest on a wall near the big garage doors.
  4. Take a picture with your Snapmatic and send it to Dax.
  5. Find the crowbar laying around nearby and use it to pry open shipping containers and steal their contents.
  6. Once you've collected all 5 containers of chemicals you'll be directed to go stop a train. YOU HAVE TO GO FAST.
  7. Very quickly make your way out of Humane Labs and toward the yellow dot on your map. We highly recommend off-roading for the quickest route.
  8. When you get there, you'll need to go upstairs and inside the building to pull the lever.
  9. The train will drive by and crash. Head to the area indicated on your map to collect a cutter.
  10. Next go to the crash site. You'll be attacked by enemies on foot, in cars, and one at a time in a helicopter. They will likely keep coming as you work on collecting the loot.
  11. Go up to the containers on the crashed train cars and cut them open.
  12. Some of the cars will have chemicals inside. Keep checking them until you collect all 5.
  13. Once you have all of the chemicals you'll need to steal the Brickade, which is on one of the train cars in the crash site.
  14. Drive the Brickade back to the Freakshop, avoiding too much damage, to end the mission.

The Brickade 6x6 and the Freakshop are now unlocked for your use. If you want to purchase an Acid Lab business you'll now need to steal lab equipment from a nearby warehouse.

At some point later Dax will contact you for more work, which will initiate the Last Dose missions.